5-(N,N-dimethyl)amiloride-sensitive Na-Li exchange in isolated specimens of human atrium.
نویسندگان
چکیده
منابع مشابه
Difference between human red blood cell Na+-Li+ countertransport and renal Na+-H+ exchange.
Several laboratories have reported that the activities of sodium-lithium countertransport are increased in red blood cells from patients with essential hypertension. Based on the many similarities between this transport system and the renal sodium-proton exchanger, a hypothesis has been put forth in the literature that increased red blood cell sodium-lithium countertransport activity may be a m...
متن کاملA membrane potential-sensitive Na+-H+ exchange system in flagella isolated from sea urchin spermatozoa.
Sea urchin sperm motility is activated by a Na+-dependent increase of internal pH. A flagellar preparation was used in the present study to investigate this ionic mechanism. Using 22Na and a pH electrode, the stoichiometry of Na+ uptake to H+ release in the isolated flagella was found to be 1.09 +/- 0.11. Reversing the Na+ gradient induced reacidification of the intraflagellar pH as measured by...
متن کاملKinetic evidence that the Na-PO4 cotransporter is the molecular mechanism for Na/Li exchange in human red blood cells.
The molecular basis for Na/Li exchange is unknown. Li can be transported by the Na pump, anion exchanger (AE1), a background leak, and the Na/Li exchanger. In vivo the intraerythrocyte concentration of Li results from the balance of passive entry, mostly on AE1, and the active extrusion on the Na/Li exchanger. Here we show that erythrocytes have Li-activated PO4 transport that behaves as if it ...
متن کاملThe Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension.
This review examines the physiological functions of the Li+-Na+ exchanger and Na+-K+-Cl- cotransport system in human red blood cells. Both transporters are family aggregated and determined mainly by genetic factors; they are present in kidney and vascular cells, where they are regulated by vasoactive substances. To assess the physiological function of these two transporters, we investigated the...
متن کاملClinical Studies Difference Between Human Red Blood Cell Na-Li Counter transport and Renal Na-H Exchange
Several laboratories have reported that the activities of sodium-lithium countertransport are increased in red blood cells from patients with essential hypertension. Based on the many similarities between this transport system and the renal sodium-proton exchanger, a hypothesis has been put forth in the literature that increased red blood cell sodium-lithium counter-transport activity may be a ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1988
ISSN: 0021-9738
DOI: 10.1172/jci113740